Overview
SCIENTIFIC SCORE
Possibly Effective
Based on 3 Researches
7.7
USERS' SCORE
Good
Based on 8 Reviews
8.5
Supplement Facts
Serving Size: 1 Tablet
Amount Per Serving
%DV
Vitamin B6 (as Pyridoxal-5-Phosphate)
1.5 mg
88%
Folate (400 mcg as (6S)-5-MTHF [from (6S)-5-Methyltetrahydrofolate Glucosamine Salt])
680 mcg DFE‡
170%
Vitamin B12 (as Methylcobalamin)
1,000 mcg
41,667%
Top Medical Research Studies
8
We aimed to understand how folic acid affects bone cancer pain, a challenging condition that isn't easily managed with typical treatments. In our study, we induced bone cancer pain in rats by injecting Walker 256 tumor cells into their tibia. To assess pain response, we measured how quickly they withdrew their paws in response to pressure and heat.
Throughout the study, we found that rats suffering from bone cancer pain showed a significant reduction in their pain thresholds. However, with continuous folic acid treatment, these thresholds improved, indicating a notable analgesic effect. We examined the levels of P2X2 and P2X3 receptors—known to play a role in pain signaling—and noticed they were elevated in the pain-afflicted rats. Remarkably, folic acid treatment resulted in a notable decrease in these receptors in both the spinal cord and relevant nerve ganglia.
This suggests that folic acid not only relieves pain but also acts by downregulating specific receptors associated with pain. We believe that our findings position folic acid as a promising option for alleviating bone cancer pain in clinical settings.
Throughout the study, we found that rats suffering from bone cancer pain showed a significant reduction in their pain thresholds. However, with continuous folic acid treatment, these thresholds improved, indicating a notable analgesic effect. We examined the levels of P2X2 and P2X3 receptors—known to play a role in pain signaling—and noticed they were elevated in the pain-afflicted rats. Remarkably, folic acid treatment resulted in a notable decrease in these receptors in both the spinal cord and relevant nerve ganglia.
This suggests that folic acid not only relieves pain but also acts by downregulating specific receptors associated with pain. We believe that our findings position folic acid as a promising option for alleviating bone cancer pain in clinical settings.
Read More
8
Folic acid supports bone health
We undertook a study to investigate the effects of different doses of folic acid on bone health during pregnancy, particularly focusing on bone resorption markers associated with osteoporosis. In this randomized, double-blind trial, forty-five pregnant women participated, with some taking a high dose of 5 mg per day and others taking a lower dose of 0.5 mg per day throughout their pregnancy.
Our findings indicated that higher doses of folic acid appeared to help lower important markers of bone resorption, namely soluble Receptor Activator of Nuclear Factor-Kappa B ligand (sRANKL) and Tumor Necrosis Factor alpha (TNFα), while increasing Osteoprotegerin (OPG). This balance may contribute to improved bone health, potentially reducing the risk of Pregnancy Associated Osteoporosis (PAO) in affected women.
While the study did not directly measure bone pain outcomes, the biochemical changes observed suggest an encouraging approach to support bone health and prevent complications that can lead to pain and fractures. Overall, we believe that higher folic acid doses during pregnancy may offer beneficial effects on bone metabolism, thus contributing positively to women’s health in this crucial period.
Our findings indicated that higher doses of folic acid appeared to help lower important markers of bone resorption, namely soluble Receptor Activator of Nuclear Factor-Kappa B ligand (sRANKL) and Tumor Necrosis Factor alpha (TNFα), while increasing Osteoprotegerin (OPG). This balance may contribute to improved bone health, potentially reducing the risk of Pregnancy Associated Osteoporosis (PAO) in affected women.
While the study did not directly measure bone pain outcomes, the biochemical changes observed suggest an encouraging approach to support bone health and prevent complications that can lead to pain and fractures. Overall, we believe that higher folic acid doses during pregnancy may offer beneficial effects on bone metabolism, thus contributing positively to women’s health in this crucial period.
Read More
7
We examined the potential benefits of carnitine and folic acid in reducing bone pain and fatigue in patients with beta-thalassemia minor. Over three months, 73 participants received either carnitine alone, a combination of carnitine and folic acid, or folic acid alone, while a control group went without supplementation.
Our results showed that carnitine significantly improved plasma levels and reduced bone pain and muscle weakness for those affected by this condition. Although folic acid improved red blood cell levels, its impact on bone pain was not directly highlighted. Overall, our findings suggest that carnitine can be beneficial in addressing bone pain in these patients.
Our results showed that carnitine significantly improved plasma levels and reduced bone pain and muscle weakness for those affected by this condition. Although folic acid improved red blood cell levels, its impact on bone pain was not directly highlighted. Overall, our findings suggest that carnitine can be beneficial in addressing bone pain in these patients.
Read More
Most Useful Reviews
9
Reduced joint pain
15 people found this helpful
The endocrinologist prescribed this drug for me due to elevated homocysteine and a disturbed folate cycle. I received delicious vitamins to take under the tongue. Surprisingly, I noticed significant relief from my joint pain, especially in my back, which is affected by a lumbar spine hernia. After reading about B vitamins' ability to alleviate joint pain, I realised their benefits. I began to feel ill less frequently and even bought the product for my grandson, as it truly works. This is my second purchase!
Read More
9
Numbness relief
7 people found this helpful
I developed a straight neck due to bad posture, triggering severe shoulder pain, cervical hernia, and carpal tunnel syndrome, resulting in hand numbness for two months. The thought of surgery terrified me, so I turned to vitamin B12 after reading reviews suggesting it could help. Though results weren't immediate, within a week I noticed a marked improvement, and after a month, the symptoms have largely disappeared. I highly recommend this supplement for anyone facing similar challenges.
Read More
9
Enhanced bone quality
1 people found this helpful
After using vitamin supplements to enhance my bone quality, the results have been remarkable. Over several months, I've significantly strengthened my bones and joints, allowing me to feel more mobile and confident during physical activities. These vitamins have effectively maintained my bone and joint health, and I strongly recommend them to anyone focusing on their wellbeing and an active lifestyle.
Read More
Medical Researches
SCIENTIFIC SCORE
Possibly Effective
Based on 3 Researches
7.7
- All Researches
8
We aimed to understand how folic acid affects bone cancer pain, a challenging condition that isn't easily managed with typical treatments. In our study, we induced bone cancer pain in rats by injecting Walker 256 tumor cells into their tibia. To assess pain response, we measured how quickly they withdrew their paws in response to pressure and heat.
Throughout the study, we found that rats suffering from bone cancer pain showed a significant reduction in their pain thresholds. However, with continuous folic acid treatment, these thresholds improved, indicating a notable analgesic effect. We examined the levels of P2X2 and P2X3 receptors—known to play a role in pain signaling—and noticed they were elevated in the pain-afflicted rats. Remarkably, folic acid treatment resulted in a notable decrease in these receptors in both the spinal cord and relevant nerve ganglia.
This suggests that folic acid not only relieves pain but also acts by downregulating specific receptors associated with pain. We believe that our findings position folic acid as a promising option for alleviating bone cancer pain in clinical settings.
Throughout the study, we found that rats suffering from bone cancer pain showed a significant reduction in their pain thresholds. However, with continuous folic acid treatment, these thresholds improved, indicating a notable analgesic effect. We examined the levels of P2X2 and P2X3 receptors—known to play a role in pain signaling—and noticed they were elevated in the pain-afflicted rats. Remarkably, folic acid treatment resulted in a notable decrease in these receptors in both the spinal cord and relevant nerve ganglia.
This suggests that folic acid not only relieves pain but also acts by downregulating specific receptors associated with pain. We believe that our findings position folic acid as a promising option for alleviating bone cancer pain in clinical settings.
Read More
8
Folic acid supports bone health
We undertook a study to investigate the effects of different doses of folic acid on bone health during pregnancy, particularly focusing on bone resorption markers associated with osteoporosis. In this randomized, double-blind trial, forty-five pregnant women participated, with some taking a high dose of 5 mg per day and others taking a lower dose of 0.5 mg per day throughout their pregnancy.
Our findings indicated that higher doses of folic acid appeared to help lower important markers of bone resorption, namely soluble Receptor Activator of Nuclear Factor-Kappa B ligand (sRANKL) and Tumor Necrosis Factor alpha (TNFα), while increasing Osteoprotegerin (OPG). This balance may contribute to improved bone health, potentially reducing the risk of Pregnancy Associated Osteoporosis (PAO) in affected women.
While the study did not directly measure bone pain outcomes, the biochemical changes observed suggest an encouraging approach to support bone health and prevent complications that can lead to pain and fractures. Overall, we believe that higher folic acid doses during pregnancy may offer beneficial effects on bone metabolism, thus contributing positively to women’s health in this crucial period.
Our findings indicated that higher doses of folic acid appeared to help lower important markers of bone resorption, namely soluble Receptor Activator of Nuclear Factor-Kappa B ligand (sRANKL) and Tumor Necrosis Factor alpha (TNFα), while increasing Osteoprotegerin (OPG). This balance may contribute to improved bone health, potentially reducing the risk of Pregnancy Associated Osteoporosis (PAO) in affected women.
While the study did not directly measure bone pain outcomes, the biochemical changes observed suggest an encouraging approach to support bone health and prevent complications that can lead to pain and fractures. Overall, we believe that higher folic acid doses during pregnancy may offer beneficial effects on bone metabolism, thus contributing positively to women’s health in this crucial period.
Read More
7
We examined the potential benefits of carnitine and folic acid in reducing bone pain and fatigue in patients with beta-thalassemia minor. Over three months, 73 participants received either carnitine alone, a combination of carnitine and folic acid, or folic acid alone, while a control group went without supplementation.
Our results showed that carnitine significantly improved plasma levels and reduced bone pain and muscle weakness for those affected by this condition. Although folic acid improved red blood cell levels, its impact on bone pain was not directly highlighted. Overall, our findings suggest that carnitine can be beneficial in addressing bone pain in these patients.
Our results showed that carnitine significantly improved plasma levels and reduced bone pain and muscle weakness for those affected by this condition. Although folic acid improved red blood cell levels, its impact on bone pain was not directly highlighted. Overall, our findings suggest that carnitine can be beneficial in addressing bone pain in these patients.
Read More
User Reviews
USERS' SCORE
Good
Based on 8 Reviews
8.5
- All Reviews
- Positive Reviews
- Negative Reviews
9
Reduced joint pain
15 people found this helpful
The endocrinologist prescribed this drug for me due to elevated homocysteine and a disturbed folate cycle. I received delicious vitamins to take under the tongue. Surprisingly, I noticed significant relief from my joint pain, especially in my back, which is affected by a lumbar spine hernia. After reading about B vitamins' ability to alleviate joint pain, I realised their benefits. I began to feel ill less frequently and even bought the product for my grandson, as it truly works. This is my second purchase!
Read More
9
Numbness relief
7 people found this helpful
I developed a straight neck due to bad posture, triggering severe shoulder pain, cervical hernia, and carpal tunnel syndrome, resulting in hand numbness for two months. The thought of surgery terrified me, so I turned to vitamin B12 after reading reviews suggesting it could help. Though results weren't immediate, within a week I noticed a marked improvement, and after a month, the symptoms have largely disappeared. I highly recommend this supplement for anyone facing similar challenges.
Read More
9
Enhanced bone quality
1 people found this helpful
After using vitamin supplements to enhance my bone quality, the results have been remarkable. Over several months, I've significantly strengthened my bones and joints, allowing me to feel more mobile and confident during physical activities. These vitamins have effectively maintained my bone and joint health, and I strongly recommend them to anyone focusing on their wellbeing and an active lifestyle.
Read More
9
Bone pain improvement
The chewable tablets taste great, and my entire family took them. The positive effect was particularly evident in my mother, as her chronic bone pains have disappeared.
Read More
7.5
Improved menstrual pain
10 people found this helpful
The taste is delightful, and the ingredients seem excellent as it contains folic acid and B6. I have struggled with pain in my right flank, but since taking this, I feel some improvement. A blood test indicated anemia and circulation issues, and I thought B12 deficiency was the cause of my poor health. My PMS and menstrual discomfort have also improved. I believe this supplement, combined with iron, zinc, and magnesium, could benefit others experiencing similar issues.
Read More
Frequently Asked Questions
9
Numbness relief
7 people found this helpful
I developed a straight neck due to bad posture, triggering severe shoulder pain, cervical hernia, and carpal tunnel syndrome, resulting in hand numbness for two months. The thought of surgery terrified me, so I turned to vitamin B12 after reading reviews suggesting it could help. Though results weren't immediate, within a week I noticed a marked improvement, and after a month, the symptoms have largely disappeared. I highly recommend this supplement for anyone facing similar challenges.
7.5
Less bone pain
1 people found this helpful
After taking these vitamins daily for two months, my cyanocobalamin levels normalised to 250, and I’ve noticed an improvement in my immunity. I feel less fatigue, more alert, and my bones hurt less. This supplement is crucial for brain and nerve function, and folic acid is vital for women's health. The taste is also quite pleasant.
9
Enhanced bone quality
1 people found this helpful
After using vitamin supplements to enhance my bone quality, the results have been remarkable. Over several months, I've significantly strengthened my bones and joints, allowing me to feel more mobile and confident during physical activities. These vitamins have effectively maintained my bone and joint health, and I strongly recommend them to anyone focusing on their wellbeing and an active lifestyle.
9
Reduced joint pain
15 people found this helpful
The endocrinologist prescribed this drug for me due to elevated homocysteine and a disturbed folate cycle. I received delicious vitamins to take under the tongue. Surprisingly, I noticed significant relief from my joint pain, especially in my back, which is affected by a lumbar spine hernia. After reading about B vitamins' ability to alleviate joint pain, I realised their benefits. I began to feel ill less frequently and even bought the product for my grandson, as it truly works. This is my second purchase!
9
Bone pain improvement
The chewable tablets taste great, and my entire family took them. The positive effect was particularly evident in my mother, as her chronic bone pains have disappeared.
7.5
Improved menstrual pain
10 people found this helpful
The taste is delightful, and the ingredients seem excellent as it contains folic acid and B6. I have struggled with pain in my right flank, but since taking this, I feel some improvement. A blood test indicated anemia and circulation issues, and I thought B12 deficiency was the cause of my poor health. My PMS and menstrual discomfort have also improved. I believe this supplement, combined with iron, zinc, and magnesium, could benefit others experiencing similar issues.
7
We examined the potential benefits of carnitine and folic acid in reducing bone pain and fatigue in patients with beta-thalassemia minor. Over three months, 73 participants received either carnitine alone, a combination of carnitine and folic acid, or folic acid alone, while a control group went without supplementation.
Our results showed that carnitine significantly improved plasma levels and reduced bone pain and muscle weakness for those affected by this condition. Although folic acid improved red blood cell levels, its impact on bone pain was not directly highlighted. Overall, our findings suggest that carnitine can be beneficial in addressing bone pain in these patients.
Our results showed that carnitine significantly improved plasma levels and reduced bone pain and muscle weakness for those affected by this condition. Although folic acid improved red blood cell levels, its impact on bone pain was not directly highlighted. Overall, our findings suggest that carnitine can be beneficial in addressing bone pain in these patients.
8
We aimed to understand how folic acid affects bone cancer pain, a challenging condition that isn't easily managed with typical treatments. In our study, we induced bone cancer pain in rats by injecting Walker 256 tumor cells into their tibia. To assess pain response, we measured how quickly they withdrew their paws in response to pressure and heat.
Throughout the study, we found that rats suffering from bone cancer pain showed a significant reduction in their pain thresholds. However, with continuous folic acid treatment, these thresholds improved, indicating a notable analgesic effect. We examined the levels of P2X2 and P2X3 receptors—known to play a role in pain signaling—and noticed they were elevated in the pain-afflicted rats. Remarkably, folic acid treatment resulted in a notable decrease in these receptors in both the spinal cord and relevant nerve ganglia.
This suggests that folic acid not only relieves pain but also acts by downregulating specific receptors associated with pain. We believe that our findings position folic acid as a promising option for alleviating bone cancer pain in clinical settings.
Throughout the study, we found that rats suffering from bone cancer pain showed a significant reduction in their pain thresholds. However, with continuous folic acid treatment, these thresholds improved, indicating a notable analgesic effect. We examined the levels of P2X2 and P2X3 receptors—known to play a role in pain signaling—and noticed they were elevated in the pain-afflicted rats. Remarkably, folic acid treatment resulted in a notable decrease in these receptors in both the spinal cord and relevant nerve ganglia.
This suggests that folic acid not only relieves pain but also acts by downregulating specific receptors associated with pain. We believe that our findings position folic acid as a promising option for alleviating bone cancer pain in clinical settings.
References
- Tabei SM, Mazloom M, Shahriari M, Zareifar S, Azimi A, et al. Determining and surveying the role of carnitine and folic acid to decrease fatigue in β-thalassemia minor subjects. Pediatr Hematol Oncol. 2013;30:742. doi:10.3109/08880018.2013.771388
- Gu YJ, Qian HY, Zhou F, Zhang L, Chen L, et al. Folic acid relieves bone cancer pain by downregulating P2X2/3 receptors in rats. Brain Res. 2023;1811:148405. doi:10.1016/j.brainres.2023.148405
- Fathi Maroufi N, Ghorbanihaghjo A, Sayyah Melli M, Vaezi M, Hekmati Azar Mehrabani Z, et al. Effects of High and Low Doses of Folic Acid on the Soluble Receptor Activator of Nuclear Factor-kappa B Ligand/Osteoprotegerin Ratio during Pregnancy. Iran J Public Health. 2017;46:517.
